Mucolytic enzyme systems. XI. Hyaluronidase inhibitor and serum mucoproteins in patients with lipoid nephrosis and acute glomerulonephritis.

Mucolytic enzyme systems; inhibition of hyaluronidase by human blood serum during the normal menstrual cycle and pregnancy.

Mucolytic enzyme systems. X. Serum hyaluronidase inhibitor in liver disease.

The hyaluronidase inhibiting property of blood serum has been found to be increased in such diverse clinical states as infectious diseases of bacterial and viral origin (1-4), neoplastic disease (5, 6), and the postpartum state in women (7) as well as in several of the so-called "collagen diseases" of unknown etiology, notably rheumatic fever (8, 9), disseminated lupus erythematosis (2) and der...

Remission of idiopathic nephrotic syndrome after treatment with cyclosporin A.

Nephrotic syndrome in minimal change lipoid nephrosis and focal segmental glomerulosclerosis may be due to alteration of glomerular anionic sites by a lymphokine. Six adults with nephrotic syndrome who were resistant to treatment with corticosteroids and immunosuppressants were treated with cyclosporin A. In three patients with minimal change lipoid nephrosis who had been nephrotic for 3.5 to 2...

Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis.

We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was gene...

Mucolytic Enzyme Systems Vii. Effects of Tissue Extracts and Body Fluids, Certain Steroids, and Hemoglobin Derivatives on Hyaluronidase Activity * by Lee W. Wattenberg

The rale of hyaluronidase as a spreading factor or invasive agent in tissues has led to studies of its occurrence in virulent bacteria, snake venoms, bee sting extracts, and spermatozoa (1, 2). Its presence in malignant cells has not been conclusively established. The earlier work of DuranReynals and Stewart (3), and the more recent studies of McCutcheon and Coman (4), on malignant tissues, fav...